反应详情

A mixture of 4.8 parts of 3-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 4 parts of 3-(4-piperidinyl)-1H-indole, 8.5 parts of sodium carbonate and 120 parts of 4-methyl-2-pentanone is stirred and refluxed overnight using a water-separator. The reaction mixture is cooled, water is added and the precipitated product is filtered off. It is dissolved in a mixture of trichloromethane and methanol (90:10 by volume). The solution is filtered over silica gel and the filtrate is evaporated. The residue is crystallized from 2-propanol, yielding 2.5 parts (31%) of 3-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one; mp. 224.9° C.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture is cooled
3. filtrationthe precipitated product is filtered off
4. dissolutionIt is dissolved in a mixture of trichloromethane and methanol (90:10 by volume)
5. filtrationThe solution is filtered over silica gel
6. customthe filtrate is evaporated
7. customThe residue is crystallized from 2-propanol