6,7-Dichloro-2-ethyl-2-(i-propyl)-1-oxoindan-5-ylacetamide → 6,7-Dichloro-2-ethyl-2-(n-propyl)-1-hydroxyindan-5-ylacetamide

HRID 66688Notes

Reaction equation

HRID 66688 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH:14]([CH3:16])[CH3:15])([CH3:13])[C:8]2=[O:12])=[CH:4][C:3]=1[CH2:17][C:18]([NH2:20])=[O:19].[Cl:21][C:22]1[C:30]([Cl:31])=[C:29]2[C:25]([CH2:26][C:27]([CH2:34][CH3:35])([CH3:33])[C:28]2=[O:32])=[CH:24][C:23]=1[CH2:36][C:37]([NH2:39])=[O:38].[Cl:40][C:41]1[C:49]([Cl:50])=[C:48]2[C:44]([CH2:45][C:46]([CH2:55][CH3:56])(C(C)C)[C:47]2=[O:51])=[CH:43][C:42]=1[CH2:57][C:58]([NH2:60])=[O:59]>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH:14]([CH3:16])[CH3:15])([CH3:13])[CH:8]2[OH:12])=[CH:4][C:3]=1[CH2:17][C:18]([NH2:20])=[O:19].[Cl:21][C:22]1[C:30]([Cl:31])=[C:29]2[C:25]([CH2:26][C:27]([CH2:34][CH3:35])([CH3:33])[CH:28]2[OH:32])=[CH:24][C:23]=1[CH2:36][C:37]([NH2:39])=[O:38].[Cl:40][C:41]1[C:49]([Cl:50])=[C:48]2[C:44]([CH2:45][C:46]([CH2:55][CH3:56])([CH2:3][CH2:2][CH3:10])[CH:47]2[OH:51])=[CH:43][C:42]=1[CH2:57][C:58]([NH2:60])=[O:59]

Participants

6

Reactant 3

HCID 539781946,7-Dichloro-2-ethyl-2-(i-propyl)-1-oxoindan-5-ylacetamideHCID 542493876,7-Dichloro-2-(i-propyl)-2-methyl-1-oxoindan-5-ylacetamideHCID 543790506,7-Dichloro-2-ethyl-2-methyl-1-oxoindan-5-ylacetamide

Product 3

HCID 540838716,7-Dichloro-2-ethyl-2-(n-propyl)-1-hydroxyindan-5-ylacetamideHCID 541928086,7-Dichloro-2-(i-propyl)-2-methyl-1-hydroxyindan-5-ylacetamideHCID 542378066,7-Dichloro-2-ethyl-2-methyl-1-hydroxyindan-5-ylacetamide

Procedure

When 6,7-dichloro-2-(i-propyl)-2-methyl-1-oxoindan-5-ylacetamide, 6,7-dichloro-2-ethyl-2-methyl-1-oxoindan-5-ylacetamide, and 6,7-dichloro-2-ethyl-2-(i-propyl)-1-oxoindan-5-ylacetamide are treated as described in Example 5, there are obtained 6,7-dichloro-2-(i-propyl)-2-methyl-1-hydroxyindan-5-ylacetamide, 6,7-dichloro-2-ethyl-2-methyl-1-hydroxyindan-5-ylacetamide and 6,7-dichloro-2-ethyl-2-(n-propyl)-1-hydroxyindan-5-ylacetamide.

Sources & evidence

ORD record
ord-cd6596c45f304f02839676ce81683ea4
Source dataset
uspto-grants-1982_08
Patent number
US04342776

Reaction notes

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