4-Hydroxymethyl-pyrrolidin-2-one → 7-(4-Hydroxymethyl-2-oxopyrrolidin-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one

HRID 667018Notes

Reaction equation

HRID 667018 reaction equation
[I:9][c:10]1[cH:11][cH:12][c:13]2[cH:14][c:15](-[c:21]3[c:22]([C:27]([F:28])([F:29])[F:30])[cH:23][cH:24][cH:25][cH:26]3)[nH:16][c:17](=[O:20])[c:18]2[cH:19]1.[OH:1][CH2:2][CH:3]1[CH2:4][C:5](=[O:8])[NH:6][CH2:7]1>>[OH:1][CH2:2][CH:3]1[CH2:4][C:5](=[O:8])[N:6]([c:10]2[cH:11][cH:12][c:13]3[cH:14][c:15](-[c:21]4[c:22]([C:27]([F:28])([F:29])[F:30])[cH:23][cH:24][cH:25][cH:26]4)[nH:16][c:17](=[O:20])[c:18]3[cH:19]2)[CH2:7]1

Participants

3

Reactant 2

HCID 152563274-Hydroxymethyl-pyrrolidin-2-oneHCID 231568037-iodo-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one

Product 1

HCID 118570997-(4-Hydroxymethyl-2-oxopyrrolidin-1-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one

Sources & evidence

ORD record
ord-5e7c0e5814564eb8869bbcecd3c3c2f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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