Ethanol → 6-Isopropyl-3-methoxy-5-ethoxy-6H-1,2,4,6-thiatriazine-1,1-dioxide

Participants

Reaction Conditions

Reaction Steps

28.7 parts by weight of 5-chloro-6-isopropyl-3- methoxy-6H-1,2,4,6-thiatriazine-1,1-dioxide were added, a little at a time, in the course of 10 minutes, to a stirred mixture of 12.2 parts of triethylamine and 90 parts of absolute ethanol at 20°-25° C. After 3 hours' stirring at 25° C., the reaction mixture was evaporated down under reduced pressure, the residue was taken up in methylene chloride and the solution was washed with 10% strength sodium carbonate solution. After drying over magnesium sulfate, chromatography over alumina and evaporating down under reduced presure, 24 parts of 6-isopropyl-33-methoxy-5-ethoxy-6H-1,2,4,6-thiatriazine-1,1-dioxide, of melting point 81°-85° C. were obtained.

Provenance & Evidence