反应详情

温度

110 °C

246 grams of cyclohexene is added to a stirred slurry of p-methyl phenyl beta ethanol (408 grams) and 25 grams of Amberlyst® 15 cation exchange resin maintained at 110° C., over a 2 hour period. The reaction mass is then aged at 110° C. for an additional 3 hours whereupon it is cooled and filtered. The resulting solution is then heated at reflux with 80 grams of 30% aqueous sodium hydroxide. The reaction mass is then cooled and the resulting organic layer is washed with 1 liter of water. The organic layer is separated from the reaction mass and distilled through a 11/2"×12" Goodlow packed column to afford the following distillation fractions:

1. temperatureis cooled
2. filtrationfiltered
3. temperatureThe resulting solution is then heated
4. temperatureat reflux with 80 grams of 30% aqueous sodium hydroxide
5. temperatureThe reaction mass is then cooled
6. washthe resulting organic layer is washed with 1 liter of water
7. customThe organic layer is separated from the reaction mass
8. distillationdistilled through a 11/2"×12" Goodlow
9. customto afford
10. distillationthe following distillation fractions