6-Bromopyridine-3-carbonitrile → 6-{7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl}nicotinonitrile

HRID 667133Notes

Reaction equation

HRID 667133 reaction equation
[Br:25][c:26]1[n:27][cH:28][c:29]([C:30]#[N:31])[cH:32][cH:33]1.[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[n:9][c:10]([NH2:24])[n:11][c:12](-[c:14]3[cH:15][cH:16][c:17]4[c:22]([cH:23]3)[CH2:21][NH:20][CH2:19][CH2:18]4)[cH:13]2)[CH2:6][CH2:7]1>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[n:9][c:10]([NH2:24])[n:11][c:12](-[c:14]3[cH:15][cH:16][c:17]4[c:22]([cH:23]3)[CH2:21][N:20]([c:26]3[n:27][cH:28][c:29]([C:30]#[N:31])[cH:32][cH:33]3)[CH2:19][CH2:18]4)[cH:13]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 50057186-Bromopyridine-3-carbonitrileHCID 497794384-(4-Methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine

Product 1

HCID 594967016-{7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl}nicotinonitrile

Sources & evidence

ORD record
ord-41e6faec3bc44870b4a868d3b58bcd71
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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