反应详情

13.2 gm of N-(2-hydroxy-propyl)-benzimidazolone were issolved in 150 ml of dioxane, and after addition of 8 ml of SOCl2 the mixture was refluxed for one hour. After evaporation is vacuo, the residue was dissolved in ethyl acetate, and the solution was washed with a sodium bicarbonate solution and water, and dried over Na2SO4. After distilling off the solvent, 13.4 gm of N-(2-chloro-propyl)-benzimidazolone were obtained.

1. temperaturewas refluxed for one hour
2. customAfter evaporation
3. dissolutionthe residue was dissolved in ethyl acetate
4. washthe solution was washed with a sodium bicarbonate solution and water
5. dry with materialdried over Na2SO4
6. distillationAfter distilling off the solvent