反应详情

To a stirred mixture of 415 mg. of N-decyl-3-(3-[4-carboxy-2-oxo-pyrrolidino]phenyl)propenamide and 15 ml. of 1,2-dimethoxyethane is added a solution of 1.5 mmoles of diazomethane in 5 ml. of ether. The reaction mixture is stirred at room temperature for 16 hours, and then the excess diazomethane is decomposed by the addition of a few drops of acetic acid. The total solvents are removed by evaporation in vacuo, and the residue is dissolved in ethyl acetate. The ethyl acetate solution is washed with 1 N sodium hydroxide, followed by water, followed by saturated sodium chloride solution, and then dried using sodium sulfate. Evaporation of the dried ethyl acetate solution in vacuo affords the title compound.

1. additionTo a stirred mixture of 415 mg
2. customThe total solvents are removed by evaporation in vacuo
3. dissolutionthe residue is dissolved in ethyl acetate
4. washThe ethyl acetate solution is washed with 1 N sodium hydroxide
5. customdried
6. customEvaporation of the dried ethyl acetate solution in vacuo