Dichloromethane → Methyl 2-(chloromethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

HRID 668167Notes

Reaction equation

HRID 668167 reaction equation
[Cl:26][CH2:27][Cl:28].[F:5][c:6]1[c:7](-[c:14]2[c:15]([CH2:24][OH:25])[cH:16][c:17]([C:20](=[O:21])[O:22][CH3:23])[cH:18][cH:19]2)[cH:8][c:9]([O:12][CH3:13])[cH:10][cH:11]1.[S:1]([Cl:2])([Cl:3])=[O:4]>>[Cl:3][CH2:24][c:15]1[c:14](-[c:7]2[c:6]([F:5])[cH:11][cH:10][c:9]([O:12][CH3:13])[cH:8]2)[cH:19][cH:18][c:17]([C:20](=[O:21])[O:22][CH3:23])[cH:16]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 57707070Methyl 2'-fluoro-2-(hydroxymethyl)-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Product 1

HCID 57706039Methyl 2-(chloromethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Sources & evidence

ORD record
ord-a643271195af428ebd4fb110f3d5654f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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