HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 5-hydroxy-3-phenyl-1H-indole-2-carboxylate | HCID 11550917 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester | HCID 4777862 | — |
Reaction Steps
Twenty-six grams (92.4 m mole) of 5-hydroxy-3-phenyl-1H-2-indole carboxylic acid ethylester were refluxed for four days with 27.6 g of potassium carbonate and 11 ml (92.4 mole) of benzylbromide in 700 ml of methyl-ethylketone. After filtration and evaporation, the residue was chromatographed on silicagel (solvent: toluene).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04343811 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-0cfe56dcc81144c48b41a140a5ebcfd0 |
| Source note | uspto-grants-1982_08 |