Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[3-(4-Methoxy-phenyl)-2-methyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66833Notes

Reaction equation

HRID 66833 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[NH:11][C:10]=2[CH3:19])=[CH:5][CH:4]=1.[CH2:20]([O:22][C:23](=[O:28])[C:24](Br)([CH3:26])[CH3:25])[CH3:21]>>[CH2:20]([O:22][C:23](=[O:28])[C:24]([O:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]([CH3:19])=[C:9]2[C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=1)([CH3:26])[CH3:25])[CH3:21]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205291283-(4-methoxyphenyl)-2-methyl-1H-indole-5-ol

Product 1

HCID 542081332-[3-(4-Methoxy-phenyl)-2-methyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Procedure

This compound was prepared from 3-(4-methoxyphenyl)-2-methyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester analogously to Example 10.

Sources & evidence

ORD record
ord-7753051a750f4bcc9451c2ee937428aa
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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