Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[3-(3-Chloro-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66838Notes

Reaction equation

HRID 66838 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=3)[N:10]([CH3:18])[C:9]=2[CH3:19])[CH:5]=[CH:6][CH:7]=1.[CH2:20]([O:22][C:23](=[O:28])[C:24](Br)([CH3:26])[CH3:25])[CH3:21]>>[CH2:20]([O:22][C:23](=[O:28])[C:24]([O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:18])[C:9]([CH3:19])=[C:8]2[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)([CH3:26])[CH3:25])[CH3:21]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529093HCID 20529093, compound

Product 1

HCID 538233482-[3-(3-Chloro-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 3-(3-chlorophenyl)-1,2-dimethyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester analogously to Example 10.

Sources & evidence

ORD record
ord-765e7d055d2f4ab9ac551e166a26bbdd
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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