Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[2-methyl-3-(3-methyl-phenyl)-1H-indole-5-yloxy]-propanoic acid ethylester

HRID 66845Notes

Reaction equation

HRID 66845 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=1)=[CH:8][C:7]([OH:18])=[CH:6][CH:5]=2.[CH2:19]([O:21][C:22](=[O:27])[C:23](Br)([CH3:25])[CH3:24])[CH3:20]>>[CH2:19]([O:21][C:22](=[O:27])[C:23]([CH3:25])([O:18][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[NH:3][C:2]([CH3:1])=[C:10]2[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=1)[CH3:24])[CH3:20]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205290802-methyl-3-(3-methyl-phenyl)-1H-indole-5-ol

Product 1

HCID 537583822-Methyl-2-[2-methyl-3-(3-methyl-phenyl)-1H-indole-5-yloxy]-propanoic acid ethylester

Procedure

The above compound was prepared from 2-methyl-3-(3-methyl-phenyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-d8d18b12e1a44988918bb77b6d0e2381
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

Loading…