Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[1,2-dimethyl-3-(3-methyl-phenyl)-1H-indole-5-yloxy]-propanoic acid ethylester

HRID 66846Notes

Reaction equation

HRID 66846 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([OH:11])=[CH:8][CH:9]=2)[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[CH:13]=2)=[C:3]1[CH3:19].[CH2:20]([O:22][C:23](=[O:28])[C:24](Br)([CH3:26])[CH3:25])[CH3:21]>>[CH2:20]([O:22][C:23](=[O:28])[C:24]([CH3:26])([O:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:2]([CH3:1])[C:3]([CH3:19])=[C:4]2[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[CH:13]=1)[CH3:25])[CH3:21]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205291191,2-dimethyl-3-(3-methyl-phenyl)-1H-indole-5-ol

Product 1

HCID 539238672-Methyl-2-[1,2-dimethyl-3-(3-methyl-phenyl)-1H-indole-5-yloxy]-propanoic acid ethylester

Procedure

In accordance with a procedure analogous to that of Example 10, the above compound was prepared from 1,2-dimethyl-3-(3-methyl-phenyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester.

Sources & evidence

ORD record
ord-822af3560b434ac781aac7e13f50e5c7
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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