Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-{3-[2-(4-Chloro-phenyl)-ethyl]-2-methyl-1-propyl-1H-indole-5-yloxy}-2-methyl-propanoic acid ethylester

HRID 66851Notes

Reaction equation

HRID 66851 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=3)[N:12]([CH2:20][CH2:21][CH3:22])[C:11]=2[CH3:23])=[CH:4][CH:3]=1.[CH2:24]([O:26][C:27](=[O:32])[C:28](Br)([CH3:30])[CH3:29])[CH3:25]>>[CH2:24]([O:26][C:27](=[O:32])[C:28]([O:19][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:20][CH2:21][CH3:22])[C:11]([CH3:23])=[C:10]2[CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)([CH3:30])[CH3:29])[CH3:25]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529204HCID 20529204, compound

Product 1

HCID 542660522-{3-[2-(4-Chloro-phenyl)-ethyl]-2-methyl-1-propyl-1H-indole-5-yloxy}-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 3-[2-(4-chloro-phenyl)-ethyl]-2-methyl-1-propyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-34104f24a2474e13b18cf5c99baa4553
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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