Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[2-methyl-3-(4-pyridyl)-1H-indole-5-yloxy]-propanoic acid ethylester

HRID 66854Notes

Reaction equation

HRID 66854 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)=[CH:8][C:7]([OH:17])=[CH:6][CH:5]=2.[CH2:18]([O:20][C:21](=[O:26])[C:22](Br)([CH3:24])[CH3:23])[CH3:19]>>[CH2:18]([O:20][C:21](=[O:26])[C:22]([CH3:24])([O:17][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[NH:3][C:2]([CH3:1])=[C:10]2[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[CH3:23])[CH3:19]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529217HCID 20529217, compound

Product 1

HCID 542823422-Methyl-2-[2-methyl-3-(4-pyridyl)-1H-indole-5-yloxy]-propanoic acid ethylester

Procedure

The above compound was prepared from 2-methyl-3-(4-pyridyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-41f04a67a76e43fbbe602296aada1648
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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