Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[2-Benzyl-3-(4-pyridyl)-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66856Notes

Reaction equation

HRID 66856 reaction equation
[CH2:1]([C:8]1[NH:9][C:10]2[C:15]([C:16]=1[C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1)=[CH:14][C:13]([OH:23])=[CH:12][CH:11]=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:24]([O:26][C:27](=[O:32])[C:28](Br)([CH3:30])[CH3:29])[CH3:25]>>[CH2:24]([O:26][C:27](=[O:32])[C:28]([O:23][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[C:16]2[C:17]1[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=1)([CH3:30])[CH3:29])[CH3:25]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205291742-benzyl-3-(4-pyridyl)-1H-indole-5-ol

Product 1

HCID 544299062-[2-Benzyl-3-(4-pyridyl)-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 2-benzyl-3-(4-pyridyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-8e7bd4c2217c4f9780c50df7315bb7cb
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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