Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[1,2-dimethyl-3-(2-pyridyl)-1H-indole-5-yloxy]-propanoic acid ethylester

HRID 66864Notes

Reaction equation

HRID 66864 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([OH:11])=[CH:8][CH:9]=2)[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[C:3]1[CH3:18].[CH2:19]([O:21][C:22](=[O:27])[C:23](Br)([CH3:25])[CH3:24])[CH3:20]>>[CH2:19]([O:21][C:22](=[O:27])[C:23]([CH3:25])([O:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:2]([CH3:1])[C:3]([CH3:18])=[C:4]2[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)[CH3:24])[CH3:20]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529211HCID 20529211, compound

Product 1

HCID 538110172-Methyl-2-[1,2-dimethyl-3-(2-pyridyl)-1H-indole-5-yloxy]-propanoic acid ethylester

Procedure

The above compound was prepared from 1,2-dimethyl-3-(2-pyridyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-c409da96590d4a4397c20ea3c572be71
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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