Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[2-(4-Chloro-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66866Notes

Reaction equation

HRID 66866 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:19][CH2:20][CH3:21])[C:10]3[C:15]([C:16]=2[CH3:17])=[CH:14][C:13]([OH:18])=[CH:12][CH:11]=3)=[CH:4][CH:3]=1.[CH2:22]([O:24][C:25](=[O:30])[C:26](Br)([CH3:28])[CH3:27])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:30])[C:26]([O:18][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:19][CH2:20][CH3:21])[C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)=[C:16]2[CH3:17])([CH3:28])[CH3:27])[CH3:23]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529082HCID 20529082, compound

Product 1

HCID 537408532-[2-(4-Chloro-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 2-(4-chloro-phenyl)-3-methyl-1-propyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-d62a419f8a614002af7a06a1b26fee46
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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