Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[2-(4-Methoxy-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66867Notes

Reaction equation

HRID 66867 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH2:20][CH2:21][CH3:22])[C:11]3[C:16]([C:17]=2[CH3:18])=[CH:15][C:14]([OH:19])=[CH:13][CH:12]=3)=[CH:5][CH:4]=1.[CH2:23]([O:25][C:26](=[O:31])[C:27](Br)([CH3:29])[CH3:28])[CH3:24]>>[CH2:23]([O:25][C:26](=[O:31])[C:27]([O:19][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH2:20][CH2:21][CH3:22])[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[C:17]2[CH3:18])([CH3:29])[CH3:28])[CH3:24]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529188HCID 20529188, compound

Product 1

HCID 545302572-[2-(4-Methoxy-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Procedure

In accordance with a procedure analogous to that of Example 10, the above compound was prepared from 2-(4-methoxy-phenyl)-3-methyl-1-propyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester.

Sources & evidence

ORD record
ord-ec84cde5284647c6a3a71ffd4d5f102f
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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