Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[1,3-dimethyl-2-(4-pyridyl)-1H-indole-5-yloxy]-propanoic acid ethylester

HRID 66868Notes

Reaction equation

HRID 66868 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([OH:11])=[CH:8][CH:9]=2)[C:4]([CH3:12])=[C:3]1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1.[CH2:19]([O:21][C:22](=[O:27])[C:23](Br)([CH3:25])[CH3:24])[CH3:20]>>[CH2:19]([O:21][C:22](=[O:27])[C:23]([CH3:25])([O:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:2]([CH3:1])[C:3]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)=[C:4]2[CH3:12])[CH3:24])[CH3:20]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529213HCID 20529213, compound

Product 1

HCID 540389892-Methyl-2-[1,3-dimethyl-2-(4-pyridyl)-1H-indole-5-yloxy]-propanoic acid ethylester

Procedure

The above compound was prepared from 1,3-dimethyl-2-(4-pyridyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-8c0c703b46db48e8b1912f4af97ac928
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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