Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[7,8,9,10-Tetrahydro-11-(4-pyridyl)-6H-azepino[1,2-a]indole-3-yloxy]-2-methyl-propanoic acid ethylester

HRID 66872Notes

Reaction equation

HRID 66872 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]3[C:10](=[CH:11][C:12]([OH:16])=[CH:13][CH:14]=3)[N:9]3[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:8]=23)=[CH:3][CH:2]=1.[CH2:22]([O:24][C:25](=[O:30])[C:26](Br)([CH3:28])[CH3:27])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:30])[C:26]([O:16][C:12]1[CH:11]=[C:10]2[C:15]([C:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)=[C:8]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][N:9]32)=[CH:14][CH:13]=1)([CH3:28])[CH3:27])[CH3:23]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205291797,8,9,10-Tetrahydro-11-(4-pyridyl)-6H-azepino[1,2-a]indole-3-ol

Product 1

HCID 543754252-[7,8,9,10-Tetrahydro-11-(4-pyridyl)-6H-azepino[1,2-a]indole-3-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 7,8,9,10-tetrahydro-11-(4-pyridyl)-6H-azepino[1,2-a]indole-3-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-f93422808d844528ae50419ebef8baf1
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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