Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[7,8,9,10-Tetrahydro-1,3-dimethyl-11-(4-pyridyl)-6H-azepino[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid ethylester

HRID 66873Notes

Reaction equation

HRID 66873 reaction equation
[CH3:1][C:2]1[C:10]([OH:11])=[C:9]([CH3:12])[CH:8]=[C:7]2[C:3]=1[C:4]([C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)=[C:5]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][N:6]12.[CH2:24]([O:26][C:27](=[O:32])[C:28](Br)([CH3:30])[CH3:29])[CH3:25]>>[CH2:24]([O:26][C:27](=[O:32])[C:28]([O:11][C:10]1[C:2]([CH3:1])=[C:3]2[C:7](=[CH:8][C:9]=1[CH3:12])[N:6]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:5]1=[C:4]2[C:18]1[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=1)([CH3:30])[CH3:29])[CH3:25]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529087HCID 20529087, compound

Product 1

HCID 540138622-[7,8,9,10-Tetrahydro-1,3-dimethyl-11-(4-pyridyl)-6H-azepino[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 7,8,9,10-tetrahydro-1,3-dimethyl-11-(4-pyridyl)-6H-azepino[1,2-a]indole-2-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-a30fe287ec044fca84c4f045d0fd241a
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

Loading…