Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[7,8,9,10-Tetrahydro-11-(2-pyridyl)-6H-azepino[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid ethylester

HRID 66874Notes

Reaction equation

HRID 66874 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([OH:16])[CH:14]=2)[N:9]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:8]=12.[CH2:22]([O:24][C:25](=[O:30])[C:26](Br)([CH3:28])[CH3:27])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:30])[C:26]([O:16][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[N:9]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:8]1=[C:7]2[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)([CH3:28])[CH3:27])[CH3:23]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529152HCID 20529152, compound

Product 1

HCID 541550262-[7,8,9,10-Tetrahydro-11-(2-pyridyl)-6H-azepino[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 7,8,9,10-tetrahydro-11-(2-pyridyl)-6H-azepino[1,2-a]indole-2-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-b95b1dc5289540c2947e3a1036bb801b
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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