Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[6,7,8,9-Tetrahydro-10-(4-pyridyl)-pyrido[1,2-a]indole-2-yloxy]-2-methyl-propanoic acid ethylester
Reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([OH:16])[CH:14]=3)[N:9]3[CH2:17][CH2:18][CH2:19][CH2:20][C:8]=23)=[CH:3][CH:2]=1.[CH2:21]([O:23][C:24](=[O:29])[C:25](Br)([CH3:27])[CH3:26])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:29])[C:25]([O:16][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[N:9]1[CH2:17][CH2:18][CH2:19][CH2:20][C:8]1=[C:7]2[C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1)([CH3:27])[CH3:26])[CH3:22]Participants
3
Procedure
The above compound was prepared from 6,7,8,9-tetrahydro-10-(4-pyridyl)-pyrido[1,2-a]indole-2-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.
Sources & evidence
- ORD record
- ord-bef62342cfe648a69fd53574ec57d173
- Source dataset
- uspto-grants-1982_08
- Patent number
- US04343811
Reaction notes
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