Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-4-yloxy]propanoic acid ethylester

HRID 66878Notes

Reaction equation

HRID 66878 reaction equation
[CH3:1][C:2]1[N:3]([CH2:18][CH2:19][CH3:20])[C:4]2[CH:5]=[CH:6][CH:7]=[C:8]([OH:17])[C:9]=2[C:10]=1[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1.[CH2:21]([O:23][C:24](=[O:29])[C:25](Br)([CH3:27])[CH3:26])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:29])[C:25]([CH3:27])([O:17][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[C:10]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)=[C:2]([CH3:1])[N:3]2[CH2:18][CH2:19][CH3:20])[CH3:26])[CH3:22]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529207HCID 20529207, compound

Product 1

HCID 539064192-Methyl-2-[2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-4-yloxy]propanoic acid ethylester

Procedure

The above compound was prepared from 2-methyl-1-propyl-3-(4-pyridyl)-1H-indole-4-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-49f4e6b9339c4a4da60dc44943a1142a
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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