Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[3-(4-Methoxy-phenyl)-1,2-dimethyl-1H-indole-7-yloxy]-2-methyl-propanoic acid ethylester

HRID 66885Notes

Reaction equation

HRID 66885 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([OH:18])[CH:14]=[CH:15][CH:16]=3)[N:11]([CH3:19])[C:10]=2[CH3:20])=[CH:5][CH:4]=1.[CH2:21]([O:23][C:24](=[O:29])[C:25](Br)([CH3:27])[CH3:26])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:29])[C:25]([O:18][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:12]=1[N:11]([CH3:19])[C:10]([CH3:20])=[C:9]2[C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)([CH3:27])[CH3:26])[CH3:22]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205291653-(4-methoxy-phenyl)-1,2-dimethyl-1H-indole-7-ol

Product 1

HCID 543323742-[3-(4-Methoxy-phenyl)-1,2-dimethyl-1H-indole-7-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 3-(4-methoxy-phenyl)-1,2-dimethyl-1H-indole-7-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-9282cf23be8e49ae9de872492b939a92
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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