(4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acid → 4′-Fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-carboxaldehyde

HRID 668891Notes

Reaction equation

HRID 668891 reaction equation
[F:14][c:15]1[cH:16][c:17]([O:27][CH3:28])[c:18]([B:24]([OH:25])[OH:26])[cH:19][c:20]1[CH:21]([CH3:22])[CH3:23].[I:1][c:2]1[c:3]([CH:4]=[O:5])[cH:6][c:7]([C:10]([F:11])([F:12])[F:13])[cH:8][cH:9]1>>[c:2]1(-[c:18]2[c:17]([O:27][CH3:28])[cH:16][c:15]([F:14])[c:20]([CH:21]([CH3:22])[CH3:23])[cH:19]2)[c:3]([CH:4]=[O:5])[cH:6][c:7]([C:10]([F:11])([F:12])[F:13])[cH:8][cH:9]1

Participants

3

Reactant 2

HCID 53363739(4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acidHCID 716509062-Iodo-5-(trifluoromethyl)benzaldehyde

Product 1

HCID 591352254′-Fluoro-2′-methoxy-5′-(1-methylethyl)-4-(trifluoromethyl)[1,1′-biphenyl]-2-carboxaldehyde

Sources & evidence

ORD record
ord-15dd80d60f7b456ebaa3bbd231902702
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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