3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-ol → 2-[3-(4-Chloro-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanoic acid amylester

HRID 66894Notes

Reaction equation

HRID 66894 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=3)[N:10]([CH3:18])[C:9]=2[CH3:19])=[CH:4][CH:3]=1.[CH2:20]([O:25][C:26](=[O:31])[C:27](Br)([CH3:29])[CH3:28])[CH2:21][CH2:22][CH2:23][CH3:24]>>[CH2:20]([O:25][C:26](=[O:31])[C:27]([O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH3:18])[C:9]([CH3:19])=[C:8]2[C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)([CH3:29])[CH3:28])[CH2:21][CH2:22][CH2:23][CH3:24]

Participants

3

Reactant 2

HCID 205291643-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-olHCID 536730852-Bromo-2-methyl-propanoic acid amylester

Product 1

HCID 538241202-[3-(4-Chloro-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanoic acid amylester

Procedure

The above compound was prepared from 3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid amylester using a procedure analogous to that of Example 102.

Sources & evidence

ORD record
ord-75cdc0ecf169453d8eb0a6f2abf7a0cd
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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