Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[3-(4-Chloro-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66895Notes

Reaction equation

HRID 66895 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=3)[N:10]([CH2:18][CH2:19][CH3:20])[C:9]=2[CH3:21])=[CH:4][CH:3]=1.[CH2:22]([O:24][C:25](=[O:30])[C:26](Br)([CH3:28])[CH3:27])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:30])[C:26]([O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH2:18][CH2:19][CH3:20])[C:9]([CH3:21])=[C:8]2[C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)([CH3:28])[CH3:27])[CH3:23]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529111HCID 20529111, compound

Product 1

HCID 544250362-[3-(4-Chloro-phenyl)-2-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Procedure

In accordance with a procedure analogous to that of Example 10, the above compound was prepared from 3-(4-chloro-phenyl)-2-methyl-1-propyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester.

Sources & evidence

ORD record
ord-3b6d3fd123a04c3ea2ac47ab5b67c9c5
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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