Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-[3-(4-Chloro-phenyl)-1-dodecyl-2-methyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66896Notes

Reaction equation

HRID 66896 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=3)[N:10]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:9]=2[CH3:30])=[CH:4][CH:3]=1.[CH2:31]([O:33][C:34](=[O:39])[C:35](Br)([CH3:37])[CH3:36])[CH3:32]>>[CH2:31]([O:33][C:34](=[O:39])[C:35]([O:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:9]([CH3:30])=[C:8]2[C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)([CH3:37])[CH3:36])[CH3:32]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205291463-(4chlorophenyl)-1-dodecyl-2-methyl-1H-indole-5-ol

Product 1

HCID 545228772-[3-(4-Chloro-phenyl)-1-dodecyl-2-methyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Procedure

The above compound was prepared from 3-(4chlorophenyl)-1-dodecyl-2-methyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-79b4e800e87d4003a6c632fb76a266b6
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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