Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[3-methyl-2-(4-nitro-phenyl)-1-propyl-1H-indole-5-yloxy]propanoic acid ethylester

HRID 66900Notes

Reaction equation

HRID 66900 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([OH:11])[CH:9]=2)[N:4]([CH2:12][CH2:13][CH3:14])[C:3]=1[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1.[CH2:24]([O:26][C:27](=[O:32])[C:28](Br)([CH3:30])[CH3:29])[CH3:25]>>[CH2:24]([O:26][C:27](=[O:32])[C:28]([CH3:30])([O:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N:4]([CH2:12][CH2:13][CH3:14])[C:3]([C:15]1[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=1)=[C:2]2[CH3:1])[CH3:29])[CH3:25]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 205291083-Methyl-2-(4-nitro-phenyl)-1-propyl-1H-indole-5-ol

Product 1

HCID 705477922-Methyl-2-[3-methyl-2-(4-nitro-phenyl)-1-propyl-1H-indole-5-yloxy]propanoic acid ethylester

Procedure

The above compound was prepared from 3-methyl-2-(4-nitro-phenyl)-1-propyl-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-5bc3b3d26a3748f090f82511a299bd39
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

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