Propanoic acid, 2-bromo-2-methyl-, ethyl ester → 2-Methyl-2-[1-propyl-3-(4-pyridylmethyl)-1H-indole-5-yloxy]-propanoic acid ethylester

HRID 66902Notes

Reaction equation

HRID 66902 reaction equation
[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([OH:13])=[CH:10][CH:11]=2)[C:6]([CH2:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)=[CH:5]1)[CH2:2][CH3:3].[CH2:21]([O:23][C:24](=[O:29])[C:25](Br)([CH3:27])[CH3:26])[CH3:22]>>[CH2:21]([O:23][C:24](=[O:29])[C:25]([CH3:27])([O:13][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[N:4]([CH2:1][CH2:2][CH3:3])[CH:5]=[C:6]2[CH2:14][C:15]1[CH:16]=[CH:17][N:18]=[CH:19][CH:20]=1)[CH3:26])[CH3:22]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 20529131HCID 20529131, compound

Product 1

HCID 542232282-Methyl-2-[1-propyl-3-(4-pyridylmethyl)-1H-indole-5-yloxy]-propanoic acid ethylester

Procedure

The above compound was prepared from 1-propyl-3-(4-pyridylmethyl)-1H-indole-5-ol and 2-bromo-2-methyl-propanoic acid ethylester using a procedure analogous to that of Example 10.

Sources & evidence

ORD record
ord-d3ee7577ea4c497784834105b0d579ce
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

Loading…