Water → Tert-butyl 4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxylate

HRID 669033Notes

Reaction equation

HRID 669033 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][cH:16][c:17]([O:20][C:21]([F:22])([F:23])[F:24])[cH:18][cH:19]2)([OH:25])[CH2:12][CH2:13]1.[Cl:27][CH2:28][Cl:29].[OH2:26]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][cH:16][c:17]([O:20][C:21]([F:22])([F:23])[F:24])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 962WaterHCID 6344DichloromethaneHCID 68626953tert-Butyl 4-hydroxy-4-(4-(trifluoromethoxy)phenyl)piperidine-1-carboxylate

Product 1

HCID 57666893Tert-butyl 4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7a02a462072346c8a913534b03a42422
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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