Propanoic acid, 2-((3-(4-chlorophenyl)-1,2-dimethyl-1H-indol-5-yl)oxy)-2-methyl- → 2-[3-(4-chloro-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methylpropanol

HRID 66907Notes

Reaction equation

HRID 66907 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]([CH3:23])([CH3:22])[C:19](O)=[O:20])[CH:15]=3)[N:10]([CH3:24])[C:9]=2[CH3:25])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]([CH3:22])([CH3:23])[CH2:19][OH:20])[CH:15]=3)[N:10]([CH3:24])[C:9]=2[CH3:25])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 3059432Propanoic acid, 2-((3-(4-chlorophenyl)-1,2-dimethyl-1H-indol-5-yl)oxy)-2-methyl-HCID 21226445Aluminium lithium hydride

Product 1

HCID 205291772-[3-(4-chloro-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methylpropanol

Procedure

The above compound was prepared from 2-[3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methyl-propanoic acid and lithiumaluminium hydride using a procedure analogous to that of Example 125.

Sources & evidence

ORD record
ord-3ebb7507bced465e9b12366536050d5b
Source dataset
uspto-grants-1982_08
Patent number
US04343811

Reaction notes

Loading…