反应详情

A solution of 6.0 g (60 m mole) of chromium trioxide in 50 ml of glacial acetic acid and 5 ml of water was added dropwise to a mixture of 19.0 g (55 m mole) of 2-[3-(4-chloro-phenyl)-1,2-dimethyl-1H-indole-5-yloxy]-2-methylpropanol, 50 ml of glacial acetic acid, 10 ml of water, and 5 ml of conc. sulfuric acid under stirring. After standing overnight, the reaction mixture was warmed for one hour on a steam bath. Subsequently the mixture was extracted with chloroform. The chloroform extracts were dried, and the evaporation residue was chromatographed on silicagel with chloroform/methanol (8:2) as eluant.

1. temperaturethe reaction mixture was warmed for one hour on a steam bath
2. extractionSubsequently the mixture was extracted with chloroform
3. dry with materialThe chloroform extracts were dried
4. customthe evaporation residue was chromatographed on silicagel with chloroform/methanol (8:2) as eluant