HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Anisoyl chloride → 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Anisoyl chloride | HCID 7477 | — |
| Reactant | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 5-(4-Anisamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 13041517 | — |
Reaction Steps
A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.8 g (0.08 mole) 4-anisoyl chloride in 200 ml xylene was heated at reflux for 20 hours. Cooling of the reaction mixture resulted in precipitation of the crude product, which was then isolated by filtration. Purification was achieved by washing the crude product with hot hexane. Yield was 12.0 g (82%); m.p. 172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04343945 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-c5e879964bea48bfb1cb9bbca35b987c |
| Source note | uspto-grants-1982_08 |