反应详情

温度

-10 °C

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.6 g (0.055 mole) 3,5-dinitrobenzoyl chloride in 200 ml toluene was refluxed for 20 hours. The crude product precipitated from the reaction mixture upon cooling to -10° C. After isolation by filtration, the residue was washed with hot petroleum ether and finally recrystallized from methylene chloride to give 17.5 g (85% yield) of pure product; m.p. 197° C.

1. customThe crude product precipitated from the reaction mixture
2. filtrationAfter isolation by filtration
3. washthe residue was washed with hot petroleum ether
4. customfinally recrystallized from methylene chloride