Dichloromethane → N-{4-[(2-{[2-fluoro-5-(trifluoromethyl)phenyl]amino}-1-methyl-1H-benzimidazol-5-yl)oxy]pyridin-2-yl}-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide
Reaction equation
[B:44]([Br:45])([Br:46])[Br:47].[CH2:48]([Cl:49])[Cl:50].[F:1][c:2]1[c:3]([NH:12][c:13]2[n:14][c:15]3[c:16]([n:17]2[CH3:18])[cH:19][cH:20][c:21]([O:23][c:24]2[cH:25][c:26]([NH:30][C:31]([CH2:32][N:33]4[CH2:34][CH2:35][N:36]([CH2:39][CH2:40][O:41][CH3:42])[CH2:37][CH2:38]4)=[O:43])[n:27][cH:28][cH:29]2)[cH:22]3)[cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1>>[F:1][c:2]1[c:3]([NH:12][c:13]2[n:14][c:15]3[c:16]([n:17]2[CH3:18])[cH:19][cH:20][c:21]([O:23][c:24]2[cH:25][c:26]([NH:30][C:31]([CH2:32][N:33]4[CH2:34][CH2:35][N:36]([CH2:39][CH2:40][OH:41])[CH2:37][CH2:38]4)=[O:43])[n:27][cH:28][cH:29]2)[cH:22]3)[cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-cefd6a232f374898acfeeb92e09a1e1b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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