Boronic Acid → N-[4-(2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenyl]-methane sulfonamide

HRID 669855Notes

Reaction equation

HRID 669855 reaction equation
[BH:43]([OH:44])[OH:45].[CH3:23][C:24]1([CH3:25])[C:26]([CH3:27])([CH3:28])[O:29][B:30]([c:31]2[cH:32][cH:33][c:34]([NH:37][S:38](=[O:39])(=[O:40])[CH3:41])[cH:35][cH:36]2)[O:42]1.[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([N:8]3[CH2:9][CH2:10][O:11][CH2:12][CH2:13]3)[n:7]1)[N:14]([c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1)[CH2:15][CH2:16]2>>[c:2]1(-[c:31]2[cH:32][cH:33][c:34]([NH:37][S:38](=[O:39])(=[O:40])[CH3:41])[cH:35][cH:36]2)[c:3]2[c:4]([n:5][c:6]([N:8]3[CH2:9][CH2:10][O:11][CH2:12][CH2:13]3)[n:7]1)[N:14]([c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1)[CH2:15][CH2:16]2

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 16217653N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamideHCID 592447084-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 59244358N-[4-(2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenyl]-methane sulfonamide

Sources & evidence

ORD record
ord-b66c8e9e4af24a9e96cbc4619cdbdb60
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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