Acetone → 1-O-tert-butyl 2-O-[2-[9-[5-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]oxy-8-oxo-5,9,10,11-tetrahydronaphtho[2,3-c]isochromen-3-yl]-2-oxoethyl] 5-methylpyrrolidine-1,2-dicarboxylate

HRID 670168Notes

Reaction equation

HRID 670168 reaction equation
[C:40]([CH3:41])([CH3:42])([CH3:43])[O:44][C:45](=[O:46])[N:47]1[CH:48]([C:53](=[O:54])[OH:55])[CH2:49][CH2:50][CH:51]1[CH3:52].[C:56](=[O:57])([O-:58])[O-:59].[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([C:14](=[O:15])[O:16][CH2:17][C:18](=[O:19])[c:20]2[cH:21][cH:22][c:23]3[c:24]([cH:39]2)[CH2:25][O:26][c:27]2[cH:28][c:29]4[c:30]([cH:31][c:32]2-3)[CH2:33][CH2:34][CH:35]([Br:38])[C:36]4=[O:37])[N:6]1[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13].[CH3:62][C:63](=[O:64])[CH3:65].[Cl:66][CH2:67][Cl:68].[Cs+:60].[Cs+:61]>>[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([C:14](=[O:15])[O:16][CH2:17][C:18](=[O:19])[c:20]2[cH:21][cH:22][c:23]3[c:24]([cH:39]2)[CH2:25][O:26][c:27]2[cH:28][c:29]4[c:30]([cH:31][c:32]2-3)[CH2:33][CH2:34][CH:35]([O:55][C:53]([CH:48]2[N:47]([C:45]([O:44][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:46])[CH:51]([CH3:52])[CH2:50][CH2:49]2)=[O:54])[C:36]4=[O:37])[N:6]1[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13]

Participants

7

Reactant 6

HCID 180AcetoneHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 235120751-Tert-butoxycarbonyl-5-methyl-pyrrolidine-2-carboxylic acidHCID 776907442-O-[2-(9-bromo-8-oxo-5,9,10,11-tetrahydronaphtho[2,3-c]isochromen-3-yl)-2-oxoethyl] 1-O-tert-butyl 5-methylpyrrolidine-1,2-dicarboxylate

Product 1

HCID 776907121-O-tert-butyl 2-O-[2-[9-[5-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonyl]oxy-8-oxo-5,9,10,11-tetrahydronaphtho[2,3-c]isochromen-3-yl]-2-oxoethyl] 5-methylpyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-807f32ce923147fdaee45c69b5324bc3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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