2-Fluoro-5-(trifluoromethyl)phenylboronic acid → 4-amino-8-[2-fluoro-5-(trifluoromethyl)phenyl]-N-propyl-cinnoline-3-carboxamide
Reaction equation
[F:19][c:20]1[c:21]([B:30]([OH:31])[OH:32])[cH:22][c:23]([C:26]([F:27])([F:28])[F:29])[cH:24][cH:25]1.[NH2:1][c:2]1[c:3]([C:13](=[O:14])[NH:15][CH2:16][CH2:17][CH3:18])[n:4][n:5][c:6]2[c:7]([Br:12])[cH:8][cH:9][cH:10][c:11]12>>[NH2:1][c:2]1[c:3]([C:13](=[O:14])[NH:15][CH2:16][CH2:17][CH3:18])[n:4][n:5][c:6]2[c:7](-[c:21]3[c:20]([F:19])[cH:25][cH:24][c:23]([C:26]([F:27])([F:28])[F:29])[cH:22]3)[cH:8][cH:9][cH:10][c:11]12Participants
3
Sources & evidence
- ORD record
- ord-3abaa62d2617489d8c1803254ecfea17
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
Loading…