反应详情

29.2 g N-(2-cyanoethyl)-aniline is dissolved in 200 ml acetonitrile and then reacted with 23.97 g chloroformic acid-[3-(cyclopropylcarbonylamino)-phenyl]-ester with stirring, with which the temperature of the solution rises to about 35° C. After standing overnight the solvent is removed under vacuum, The remaining oily residue is treated with water, the water is decanted and the oil brought to crystallization with a 1:1 mixture of isopropyl ether/isopropanol. The crystallizate is finally recrystallized from isopropanol.

1. customrises to about 35° C
2. customthe solvent is removed under vacuum
3. additionThe remaining oily residue is treated with water
4. customthe water is decanted
5. customthe oil brought to crystallization with a 1:1 mixture of isopropyl ether/isopropanol
6. customThe crystallizate is finally recrystallized from isopropanol