反应详情

In this example, 2.8 g of 1-[1-(3,4-dimethoxybenzoyl)-ethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine obtained in Example 5 is mixed with 150 ml of methanol. While the mixture is stirred at 0° to 10° C., 2 g of sodium borohydride is added thereto over a period of one hour. The mixture is further stirred for 3 hours at the same temperature and then stirred overnight at room temperature. The white crystals deposited are separated by filtration, washed with methanol and water and dried to obtain 1.90 g of a crude product. The crude product is recrystallized from ethanol to obtain 1.67 g of the desired product.

1. stirringThe mixture is further stirred for 3 hours at the same temperature
2. stirringstirred overnight at room temperature
3. customThe white crystals deposited are separated by filtration
4. washwashed with methanol and water
5. customdried
6. customto obtain 1.90 g of a crude product
7. customThe crude product is recrystallized from ethanol