Acetone → tert-Butyl {1-[2-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl]piperidin-4-yl}carbamate

HRID 670754Notes

Reaction equation

HRID 670754 reaction equation
[CH3:16][S:17]([O:18][CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][CH:26]([NH:29][C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:27][CH2:28]1)(=[O:19])=[O:20].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([nH:8][c:9](=[O:12])[cH:10][n:11]2)[n:13]1.[CH3:37][O:38][c:39]1[cH:40][c:41]2[c:42]([cH:43][cH:44][c:45](=[O:46])[n:47]2[CH2:48][CH2:49][N:50]2[CH2:51][CH2:52][CH:53]([NH:54][C:55](=[O:56])[O:57][C:58]([CH3:59])([CH3:60])[CH3:61])[CH2:62][CH2:63]2)[cH:64][cH:65]1.[CH3:69][C:70](=[O:71])[CH3:72].[Cl:66][CH2:67][Cl:68].[H-:14].[Na+:15]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8]([CH2:21][CH2:22][N:23]3[CH2:24][CH2:25][CH:26]([NH:29][C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:27][CH2:28]3)[c:9](=[O:12])[cH:10][n:11]2)[n:13]1

Participants

8

Reactant 7

HCID 180AcetoneHCID 923Sodium ionHCID 6344DichloromethaneHCID 166653HydrideHCID 568344782-(4-((Tert-butoxycarbonyl)amino)piperidin-1-yl)ethyl methanesulfonateHCID 59371209tert-butyl {1-[2-(7-methoxy-2-oxoquinolin-1(2H)-yl)ethyl]piperidin-4-yl}carbamateHCID 667398036-Methoxypyrido[2,3-B]pyrazin-3(4H)-one

Product 1

HCID 57815384tert-Butyl {1-[2-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl]piperidin-4-yl}carbamate

Sources & evidence

ORD record
ord-e40f939e8a0d412ab4cc2b392b9091ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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