Sodium borohydride → 2(1H)-Quinazolinone, 3,4-dihydro-3-(1-(2-hydroxy-2-phenylethyl)-4-piperidinyl)-

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Reaction Steps

In this example, 2.30 g of 1-benzoylmethyl-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine and 100 ml of methanol are mixed and stirred at room temperature. To the stirred mixture, 1.5 g of sodium borohydride is added over a period of 5 hours. Then, the mixture is stirred overnight at room temperature. The white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 2.06 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 1.47 g of the desired product.

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