反应详情

In this example, 1.50 g of 1-(3-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine and 75 ml of methanol are mixed and stirred at room temperature. To the stirred mixture, 1.0 g of sodium borohydride is added over a period of 5 hours. Then, the mixture is stirred overnight at room temperature. The white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 1.21 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 0.87 g of the desired product.

1. stirringThen, the mixture is stirred overnight at room temperature
2. customThe white crystals deposited are separated by filtration
3. washsuccessively washed with methanol and water
4. customdried
5. customto obtain 1.21 g of a crude product
6. customThe crude product is recrystallized from a mixed solvent of chloroform and ethanol