5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-{1-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-ylamine

HRID 670891Notes

Reaction equation

HRID 670891 reaction equation
[Br:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([C:20]([F:21])([F:22])[F:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1.[NH2:24][c:25]1[n:26][cH:27][c:28]([B:31]2[O:32][C:33]([CH3:34])([CH3:35])[C:36]([CH3:37])([CH3:38])[O:39]2)[cH:29][cH:30]1>>[c:2]1(-[c:28]2[cH:27][n:26][c:25]([NH2:24])[cH:30][cH:29]2)[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([C:20]([F:21])([F:22])[F:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1

Participants

3

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 574687262-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine

Product 1

HCID 602093485-{1-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-ylamine

Sources & evidence

ORD record
ord-0fca4577abd541d68b1c4543da8026cf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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