2-Ethylpiperidine → 2,6-Bis-(2-ethylpiperidino-acetylamino)-benzo[1,2-d:5,4-d']bisthiazole

Participants

Role	Name	HCID	Charge
Reactant	2-Ethylpiperidine	HCID 94205	—
Reactant	2,6-Bis-(chloroacetyl-amino)benzo[1,2-d:5,4-d']bisthiazole	HCID 15754641	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	2-Amino-6-(2-ethylpiperidino-acetylamino)-benzo[1,2-d:5,4-d']bisthiazole	HCID 20528193	37%
Product	2,6-Bis-(2-ethylpiperidino-acetylamino)-benzo[1,2-d:5,4-d']bisthiazole	HCID 70547781	47%

Reaction Steps

A mixture of 8.0 gm of 2,6-bis-(chloroacetyl-amino)benzo[1,2-d:5,4-d']bisthiazole, 10.0 gm of 2-ethyl-piperidine and 100 ml of dioxane was refluxed for 2 hours. The reaction mixture was worked up as described in Example 16; the compounds (a) (47% of theory, from ethanol), M.P. 201°-203° C., and (b) (37% of theory, from ethanol), M.P. 223°-225° C. were isolated.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04344946
Source dataset	uspto-grants-1982_08
ORD ID	ord-94e274c4bcfd482bbb4f48b3715bdd29
Source note	uspto-grants-1982_08