反应详情

The product resulting from (a), above, is mixed with 6 g of 85% potassium hydroxide in 100 ml of aqueous ethanol and the resulting mixture heated on a steam bath for 30 minutes. The mixture is then cooled, poured into ice and extracted thrice with 25 ml portions of diethylether. The aqueous phase is filtered over Celite and the filtrate acidified with 2 N hydrochloric acid to pH 4 and cooled. The resulting precipitate is filtered, washed with ether, air dried with suction and then dried under high vacuum at 50° C. to yield the heading compound, substantially in trans form.

1. temperaturethe resulting mixture heated on a steam bath for 30 minutes
2. temperatureThe mixture is then cooled
3. additionpoured into ice
4. extractionextracted thrice with 25 ml portions of diethylether
5. filtrationThe aqueous phase is filtered over Celite
6. temperaturecooled
7. filtrationThe resulting precipitate is filtered
8. washwashed with ether, air
9. customdried with suction
10. customdried under high vacuum at 50° C.
11. customto yield the heading compound